Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3705375..3706000 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FF956_RS17385 Protein ID WP_003403218.1
Coordinates 3705375..3705776 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FF956_RS17390 Protein ID WP_003403213.1
Coordinates 3705773..3706000 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS17360 (FF956_18140) 3700464..3701411 - 948 WP_003403232.1 DUF732 domain-containing protein -
FF956_RS17365 (FF956_18145) 3701422..3702579 - 1158 WP_003903091.1 hypothetical protein -
FF956_RS17370 (FF956_18155) 3702974..3704065 - 1092 WP_003900977.1 galactokinase -
FF956_RS17375 (FF956_18160) 3704062..3705144 - 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FF956_RS17380 3705163..3705246 - 84 Protein_3429 galactose-1-phosphate uridylyltransferase -
FF956_RS17385 (FF956_18165) 3705375..3705776 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FF956_RS17390 (FF956_18170) 3705773..3706000 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FF956_RS17395 (FF956_18180) 3706195..3706437 - 243 WP_003403210.1 hypothetical protein -
FF956_RS17400 (FF956_18185) 3706434..3707183 - 750 WP_003898528.1 hypothetical protein -
FF956_RS17405 (FF956_18190) 3707267..3709834 + 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
FF956_RS17410 (FF956_18195) 3709853..3710458 - 606 WP_003898526.1 hypothetical protein -
FF956_RS17415 (FF956_18200) 3710600..3710821 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T126788 WP_003403218.1 NZ_CP040692:c3705776-3705375 [Mycobacterium tuberculosis complex sp. N0157]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T126788 NZ_CP040692:c3705776-3705375 [Mycobacterium tuberculosis complex sp. N0157]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT126788 WP_003403213.1 NZ_CP040692:c3706000-3705773 [Mycobacterium tuberculosis complex sp. N0157]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT126788 NZ_CP040692:c3706000-3705773 [Mycobacterium tuberculosis complex sp. N0157]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References