Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3699722..3700371 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FF956_RS17350 Protein ID WP_003403236.1
Coordinates 3699722..3700117 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FF956_RS17355 Protein ID WP_003403235.1
Coordinates 3700117..3700371 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS17325 (FF956_18105) 3695049..3696776 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
FF956_RS17330 (FF956_18110) 3696869..3698020 + 1152 WP_003903094.1 FIST N-terminal domain-containing protein -
FF956_RS17335 (FF956_18115) 3698092..3698499 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FF956_RS17340 (FF956_18120) 3698496..3698756 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FF956_RS17345 (FF956_18125) 3698888..3699628 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
FF956_RS17350 (FF956_18130) 3699722..3700117 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FF956_RS17355 (FF956_18135) 3700117..3700371 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FF956_RS17360 (FF956_18140) 3700464..3701411 - 948 WP_003403232.1 DUF732 domain-containing protein -
FF956_RS17365 (FF956_18145) 3701422..3702579 - 1158 WP_003903091.1 hypothetical protein -
FF956_RS17370 (FF956_18155) 3702974..3704065 - 1092 WP_003900977.1 galactokinase -
FF956_RS17375 (FF956_18160) 3704062..3705144 - 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FF956_RS17380 3705163..3705246 - 84 Protein_3429 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T126787 WP_003403236.1 NZ_CP040692:c3700117-3699722 [Mycobacterium tuberculosis complex sp. N0157]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T126787 NZ_CP040692:c3700117-3699722 [Mycobacterium tuberculosis complex sp. N0157]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT126787 WP_003403235.1 NZ_CP040692:c3700371-3700117 [Mycobacterium tuberculosis complex sp. N0157]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT126787 NZ_CP040692:c3700371-3700117 [Mycobacterium tuberculosis complex sp. N0157]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References