Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapC-mazE/PIN(toxin) |
| Location | 3660476..3661268 | Replicon | chromosome |
| Accession | NZ_CP040692 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0157 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WFB2 |
| Locus tag | FF956_RS17140 | Protein ID | WP_003403386.1 |
| Coordinates | 3660476..3660913 (+) | Length | 146 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G0TQE0 |
| Locus tag | FF956_RS17145 | Protein ID | WP_003403381.1 |
| Coordinates | 3661023..3661268 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF956_RS17115 (FF956_17895) | 3656939..3657112 | - | 174 | WP_003898549.1 | hypothetical protein | - |
| FF956_RS17120 (FF956_17900) | 3657109..3657447 | - | 339 | WP_003403405.1 | PIN domain-containing protein | - |
| FF956_RS17125 (FF956_17905) | 3657359..3657685 | - | 327 | WP_003403401.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FF956_RS17130 (FF956_17910) | 3657748..3660111 | - | 2364 | WP_003903123.1 | arylsulfatase AtsD | - |
| FF956_RS17135 (FF956_17915) | 3660225..3660479 | + | 255 | WP_003911263.1 | antitoxin VapB7 | - |
| FF956_RS17140 (FF956_17920) | 3660476..3660913 | + | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| FF956_RS17145 (FF956_17925) | 3661023..3661268 | + | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| FF956_RS17150 (FF956_17930) | 3661255..3661563 | + | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| FF956_RS17155 (FF956_17935) | 3661839..3662555 | + | 717 | WP_003903122.1 | CPBP family intramembrane metalloprotease | - |
| FF956_RS17160 (FF956_17940) | 3662631..3662786 | + | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| FF956_RS17165 (FF956_17945) | 3662881..3663264 | + | 384 | WP_003403365.1 | ribonuclease VapC6 | - |
| FF956_RS17170 (FF956_17950) | 3663652..3664662 | - | 1011 | WP_031653722.1 | ABC transporter ATP-binding protein | - |
| FF956_RS17175 (FF956_17955) | 3664743..3666248 | - | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 146 a.a. Molecular weight: 15245.39 Da Isoelectric Point: 5.1865
>T126783 WP_003403386.1 NZ_CP040692:3660476-3660913 [Mycobacterium tuberculosis complex sp. N0157]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR
Download Length: 438 bp
>T126783 NZ_CP040692:3660476-3660913 [Mycobacterium tuberculosis complex sp. N0157]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9169.01 Da Isoelectric Point: 4.2070
>AT126783 WP_003403381.1 NZ_CP040692:3661023-3661268 [Mycobacterium tuberculosis complex sp. N0157]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
Download Length: 246 bp
>AT126783 NZ_CP040692:3661023-3661268 [Mycobacterium tuberculosis complex sp. N0157]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSW5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQE0 |