Detailed information of TA system TA126781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3574211..3574920
• Replicon: chromosome
• Accession: NZ_CP040692
• Organism: Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7U4F979
• Locus tag: FF956_RS16665
• Protein ID: WP_003903160.1
• Coordinates: 3574211..3574639 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FF956_RS16670
• Protein ID: WP_003903159.1
• Coordinates: 3574663..3574920 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF956_RS16640 (FF956_17390)	3569914..3571446	+	1533	WP_003403847.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
FF956_RS16645 (FF956_17395)	3571453..3572625	+	1173	WP_003403845.1	acyl-CoA dehydrogenase family protein	-
FF956_RS16650 (FF956_17400)	3572636..3573520	+	885	WP_003403844.1	3-hydroxyisobutyrate dehydrogenase	-
FF956_RS16655 (FF956_17405)	3573589..3573834	-	246	WP_003403841.1	hypothetical protein	-
FF956_RS16660 (FF956_17410)	3573993..3574130	+	138	WP_003403839.1	hypothetical protein	-
FF956_RS16665 (FF956_17415)	3574211..3574639	-	429	WP_003903160.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF956_RS16670 (FF956_17420)	3574663..3574920	-	258	WP_003903159.1	ribbon-helix-helix protein, CopG family	Antitoxin
FF956_RS16675 (FF956_17425)	3575011..3577800	-	2790	WP_031716108.1	PE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-36)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15799.21 Da
• Isoelectric Point: 7.5536

>T126781 WP_003903160.1 NZ_CP040692:c3574639-3574211 [Mycobacterium tuberculosis complex sp. N0157]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLVLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Nucleotide

• Length: 429 bp

>T126781 NZ_CP040692:c3574639-3574211 [Mycobacterium tuberculosis complex sp. N0157]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9142.33 Da
• Isoelectric Point: 10.6530

>AT126781 WP_003903159.1 NZ_CP040692:c3574920-3574663 [Mycobacterium tuberculosis complex sp. N0157]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRVLSEVLDEGLE
LNSRK

Nucleotide

• Length: 258 bp

>AT126781 NZ_CP040692:c3574920-3574663 [Mycobacterium tuberculosis complex sp. N0157]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGGGTGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7U4F979