Detailed information of TA system TA126780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 3399014..3399633
• Replicon: chromosome
• Accession: NZ_CP040692
• Organism: Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: FF956_RS15820
• Protein ID: WP_003404726.1
• Coordinates: 3399014..3399448 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: G0TFQ5
• Locus tag: FF956_RS15825
• Protein ID: WP_003404724.1
• Coordinates: 3399454..3399633 (-)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF956_RS15795 (FF956_16495)	3394349..3395587	+	1239	WP_003404744.1	acetyl-CoA acetyltransferase	-
FF956_RS15800 (FF956_16500)	3395589..3397097	+	1509	WP_003404742.1	carotenoid oxygenase family protein	-
FF956_RS15805 (FF956_16505)	3397264..3397494	+	231	WP_003898642.1	hypothetical protein	-
FF956_RS15810 (FF956_16510)	3397629..3398078	-	450	WP_003404738.1	hypothetical protein	-
FF956_RS15815 (FF956_16515)	3398143..3398916	-	774	WP_003404735.1	VOC family protein	-
FF956_RS15820 (FF956_16520)	3399014..3399448	-	435	WP_003404726.1	SRPBCC family protein	Toxin
FF956_RS15825 (FF956_16525)	3399454..3399633	-	180	WP_003404724.1	antitoxin	Antitoxin
FF956_RS15830	3399759..3399917	-	159	WP_003404720.1	hypothetical protein	-
FF956_RS15835 (FF956_16530)	3400190..3402583	-	2394	WP_003898639.1	cation-translocating P-type ATPase	-
FF956_RS15840 (FF956_16535)	3402580..3404160	-	1581	WP_003908598.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T126780 WP_003404726.1 NZ_CP040692:c3399448-3399014 [Mycobacterium tuberculosis complex sp. N0157]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T126780 NZ_CP040692:c3399448-3399014 [Mycobacterium tuberculosis complex sp. N0157]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6394.06 Da
• Isoelectric Point: 4.3059

>AT126780 WP_003404724.1 NZ_CP040692:c3399633-3399454 [Mycobacterium tuberculosis complex sp. N0157]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT126780 NZ_CP040692:c3399633-3399454 [Mycobacterium tuberculosis complex sp. N0157]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCAGGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Antitoxin

• AlphaFold DB: G0TFQ5