Detailed information of TA system TA126775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3031637..3032325
• Replicon: chromosome
• Accession: NZ_CP040692
• Organism: Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FF956_RS14050
• Protein ID: WP_003406304.1
• Coordinates: 3031637..3032068 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FF956_RS14055
• Protein ID: WP_003406302.1
• Coordinates: 3032065..3032325 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF956_RS14025 (FF956_14645)	3028028..3028297	+	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FF956_RS14030 (FF956_14650)	3028294..3028587	+	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FF956_RS14035 (FF956_14655)	3028644..3029474	+	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FF956_RS14040 (FF956_14660)	3029555..3030415	-	861	WP_003903377.1	glycine betaine ABC transporter substrate-binding protein	-
FF956_RS14045 (FF956_14670)	3030595..3031539	+	945	Protein_2774	PE family protein	-
FF956_RS14050 (FF956_14675)	3031637..3032068	-	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF956_RS14055 (FF956_14680)	3032065..3032325	-	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FF956_RS14060 (FF956_14685)	3032401..3033390	-	990	WP_003406301.1	malate dehydrogenase	-
FF956_RS14065 (FF956_14690)	3033561..3034661	+	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FF956_RS14070 (FF956_14695)	3034738..3035919	-	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FF956_RS14075 (FF956_14700)	3035924..3036748	-	825	WP_003900298.1	trehalose ABC transporter permease SugB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T126775 WP_003406304.1 NZ_CP040692:c3032068-3031637 [Mycobacterium tuberculosis complex sp. N0157]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T126775 NZ_CP040692:c3032068-3031637 [Mycobacterium tuberculosis complex sp. N0157]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT126775 WP_003406302.1 NZ_CP040692:c3032325-3032065 [Mycobacterium tuberculosis complex sp. N0157]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT126775 NZ_CP040692:c3032325-3032065 [Mycobacterium tuberculosis complex sp. N0157]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6