Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2839401..2840056 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag FF956_RS13220 Protein ID WP_003407268.1
Coordinates 2839655..2840056 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag FF956_RS13215 Protein ID WP_003407272.1
Coordinates 2839401..2839658 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS13195 (FF956_13780) 2834588..2836555 - 1968 WP_003907654.1 primosomal protein N' -
FF956_RS13200 (FF956_13785) 2836636..2837373 - 738 WP_031647000.1 lysoplasmalogenase -
FF956_RS13205 (FF956_13790) 2837372..2838334 + 963 WP_003407279.1 alpha/beta hydrolase -
FF956_RS13210 (FF956_13795) 2838359..2839318 + 960 WP_003908687.1 alpha/beta hydrolase -
FF956_RS13215 (FF956_13800) 2839401..2839658 + 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
FF956_RS13220 (FF956_13805) 2839655..2840056 + 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
FF956_RS13225 (FF956_13810) 2840311..2842041 + 1731 WP_031653809.1 PE family protein -
FF956_RS13230 (FF956_13815) 2842087..2843121 - 1035 WP_003407264.1 AraC family transcriptional regulator -
FF956_RS13235 (FF956_13820) 2843199..2844584 + 1386 WP_003407260.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T126772 WP_003407268.1 NZ_CP040692:2839655-2840056 [Mycobacterium tuberculosis complex sp. N0157]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T126772 NZ_CP040692:2839655-2840056 [Mycobacterium tuberculosis complex sp. N0157]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT126772 WP_003407272.1 NZ_CP040692:2839401-2839658 [Mycobacterium tuberculosis complex sp. N0157]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT126772 NZ_CP040692:2839401-2839658 [Mycobacterium tuberculosis complex sp. N0157]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References