Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2442337..2442797 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag FF956_RS11430 Protein ID WP_003898996.1
Coordinates 2442337..2442585 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag FF956_RS11435 Protein ID WP_003408528.1
Coordinates 2442585..2442797 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS11410 (FF956_11920) 2438511..2439122 + 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -
FF956_RS11415 (FF956_11925) 2439112..2439513 + 402 WP_003408538.1 hypothetical protein -
FF956_RS11420 (FF956_11930) 2439798..2441498 - 1701 WP_003898998.1 serine/threonine protein kinase PknE -
FF956_RS11425 (FF956_11935) 2441592..2442329 - 738 WP_003898997.1 hypothetical protein -
FF956_RS11430 (FF956_11940) 2442337..2442585 - 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
FF956_RS11435 (FF956_11945) 2442585..2442797 - 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF956_RS11440 (FF956_11950) 2442865..2444547 + 1683 WP_003898994.1 SulP family inorganic anion transporter -
FF956_RS11445 (FF956_11955) 2444561..2444846 - 286 Protein_2261 DUF1876 domain-containing protein -
FF956_RS11450 (FF956_11960) 2445133..2446320 + 1188 WP_003908744.1 nitrate transporter NarK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T126768 WP_003898996.1 NZ_CP040692:c2442585-2442337 [Mycobacterium tuberculosis complex sp. N0157]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T126768 NZ_CP040692:c2442585-2442337 [Mycobacterium tuberculosis complex sp. N0157]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT126768 WP_003408528.1 NZ_CP040692:c2442797-2442585 [Mycobacterium tuberculosis complex sp. N0157]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT126768 NZ_CP040692:c2442797-2442585 [Mycobacterium tuberculosis complex sp. N0157]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References