Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2198581..2199125 | Replicon | chromosome |
| Accession | NZ_CP040692 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0157 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FF956_RS10330 | Protein ID | WP_003409896.1 |
| Coordinates | 2198829..2199125 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FF956_RS10325 | Protein ID | WP_003409899.1 |
| Coordinates | 2198581..2198832 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF956_RS10300 (FF956_10740) | 2194308..2195105 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
| FF956_RS10305 (FF956_10755) | 2196004..2197224 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FF956_RS10310 (FF956_10760) | 2197257..2197529 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FF956_RS10315 (FF956_10765) | 2197533..2197940 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF956_RS10320 (FF956_10770) | 2198100..2198594 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| FF956_RS10325 (FF956_10775) | 2198581..2198832 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FF956_RS10330 (FF956_10780) | 2198829..2199125 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FF956_RS10335 (FF956_10785) | 2199174..2199788 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| FF956_RS10340 (FF956_10790) | 2199677..2200222 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FF956_RS10345 (FF956_10795) | 2200219..2200668 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FF956_RS10350 (FF956_10800) | 2200710..2201087 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FF956_RS10355 | 2201062..2201583 | + | 522 | WP_003903694.1 | hypothetical protein | - |
| FF956_RS10360 (FF956_10810) | 2201557..2201868 | - | 312 | WP_003903693.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF956_RS10365 (FF956_10815) | 2201865..2202080 | - | 216 | WP_003409878.1 | antitoxin | - |
| FF956_RS10370 (FF956_10820) | 2202320..2202616 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| FF956_RS10375 (FF956_10825) | 2202617..2202808 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| FF956_RS10380 (FF956_10830) | 2202829..2203731 | + | 903 | WP_003409874.1 | hypothetical protein | - |
| FF956_RS10385 (FF956_10835) | 2203742..2204092 | + | 351 | WP_003409871.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T126765 WP_003409896.1 NZ_CP040692:2198829-2199125 [Mycobacterium tuberculosis complex sp. N0157]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T126765 NZ_CP040692:2198829-2199125 [Mycobacterium tuberculosis complex sp. N0157]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT126765 WP_003409899.1 NZ_CP040692:2198581-2198832 [Mycobacterium tuberculosis complex sp. N0157]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT126765 NZ_CP040692:2198581-2198832 [Mycobacterium tuberculosis complex sp. N0157]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |