Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2174606..2175504 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FF956_RS10190 Protein ID WP_003410001.1
Coordinates 2174944..2175504 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FF956_RS10185 Protein ID WP_003410003.1
Coordinates 2174606..2174947 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS10150 (FF956_10575) 2170259..2170615 + 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
FF956_RS10155 (FF956_10580) 2170668..2170940 + 273 WP_003903706.1 DUF1490 family protein -
FF956_RS10160 (FF956_10585) 2170937..2173252 + 2316 WP_003899120.1 cation transporter ATPase CptG -
FF956_RS10165 (FF956_10590) 2173352..2173600 + 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FF956_RS10170 (FF956_10595) 2173594..2173938 + 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FF956_RS10175 (FF956_10600) 2174027..2174362 + 336 WP_003410009.1 dehydrogenase -
FF956_RS10180 (FF956_10605) 2174263..2174520 - 258 WP_003410006.1 hypothetical protein -
FF956_RS10185 (FF956_10610) 2174606..2174947 + 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FF956_RS10190 (FF956_10615) 2174944..2175504 + 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FF956_RS10195 (FF956_10625) 2176024..2176563 - 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FF956_RS10200 (FF956_10630) 2176789..2177217 - 429 WP_003409992.1 cellulose-binding protein -
FF956_RS10205 (FF956_10635) 2177633..2178232 - 600 WP_003409989.1 L-lysine exporter -
FF956_RS10210 (FF956_10640) 2178341..2179252 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FF956_RS10215 (FF956_10645) 2179337..2179567 - 231 WP_003409980.1 DUF167 domain-containing protein -
FF956_RS10220 (FF956_10650) 2179682..2180335 + 654 WP_003409976.1 cutinase Cfp21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T126763 WP_003410001.1 NZ_CP040692:2174944-2175504 [Mycobacterium tuberculosis complex sp. N0157]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T126763 NZ_CP040692:2174944-2175504 [Mycobacterium tuberculosis complex sp. N0157]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT126763 WP_003410003.1 NZ_CP040692:2174606-2174947 [Mycobacterium tuberculosis complex sp. N0157]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT126763 NZ_CP040692:2174606-2174947 [Mycobacterium tuberculosis complex sp. N0157]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References