Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2173352..2173938 | Replicon | chromosome |
| Accession | NZ_CP040692 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0157 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | FF956_RS10170 | Protein ID | WP_003410010.1 |
| Coordinates | 2173594..2173938 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | FF956_RS10165 | Protein ID | WP_003410014.1 |
| Coordinates | 2173352..2173600 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF956_RS10145 (FF956_10570) | 2169335..2170102 | - | 768 | WP_003410019.1 | hemerythrin domain-containing protein | - |
| FF956_RS10150 (FF956_10575) | 2170259..2170615 | + | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| FF956_RS10155 (FF956_10580) | 2170668..2170940 | + | 273 | WP_003903706.1 | DUF1490 family protein | - |
| FF956_RS10160 (FF956_10585) | 2170937..2173252 | + | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| FF956_RS10165 (FF956_10590) | 2173352..2173600 | + | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| FF956_RS10170 (FF956_10595) | 2173594..2173938 | + | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| FF956_RS10175 (FF956_10600) | 2174027..2174362 | + | 336 | WP_003410009.1 | dehydrogenase | - |
| FF956_RS10180 (FF956_10605) | 2174263..2174520 | - | 258 | WP_003410006.1 | hypothetical protein | - |
| FF956_RS10185 (FF956_10610) | 2174606..2174947 | + | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| FF956_RS10190 (FF956_10615) | 2174944..2175504 | + | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| FF956_RS10195 (FF956_10625) | 2176024..2176563 | - | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| FF956_RS10200 (FF956_10630) | 2176789..2177217 | - | 429 | WP_003409992.1 | cellulose-binding protein | - |
| FF956_RS10205 (FF956_10635) | 2177633..2178232 | - | 600 | WP_003409989.1 | L-lysine exporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T126762 WP_003410010.1 NZ_CP040692:2173594-2173938 [Mycobacterium tuberculosis complex sp. N0157]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T126762 NZ_CP040692:2173594-2173938 [Mycobacterium tuberculosis complex sp. N0157]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCCGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCCGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT126762 WP_003410014.1 NZ_CP040692:2173352-2173600 [Mycobacterium tuberculosis complex sp. N0157]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT126762 NZ_CP040692:2173352-2173600 [Mycobacterium tuberculosis complex sp. N0157]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|