Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2080418..2081054 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FF956_RS09765 Protein ID WP_003904769.1
Coordinates 2080418..2080828 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag FF956_RS09770 Protein ID WP_003410651.1
Coordinates 2080821..2081054 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS09745 (FF956_10165) 2076069..2077292 + 1224 WP_003901321.1 class I SAM-dependent methyltransferase -
FF956_RS09750 (FF956_10170) 2077238..2078710 - 1473 WP_003903738.1 precorrin-2 C(20)-methyltransferase -
FF956_RS09755 (FF956_10175) 2078707..2079333 - 627 WP_003410658.1 precorrin-8X methylmutase -
FF956_RS09760 (FF956_10180) 2079343..2080434 - 1092 WP_003900454.1 precorrin-3B synthase -
FF956_RS09765 (FF956_10185) 2080418..2080828 - 411 WP_003904769.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
FF956_RS09770 (FF956_10190) 2080821..2081054 - 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
FF956_RS09775 (FF956_10195) 2081132..2084716 + 3585 WP_003410648.1 cobaltochelatase subunit CobN -
FF956_RS09780 (FF956_10200) 2084800..2085204 + 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
FF956_RS09785 2085205..2085597 - 393 WP_229303073.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14176.35 Da        Isoelectric Point: 9.4835

>T126759 WP_003904769.1 NZ_CP040692:c2080828-2080418 [Mycobacterium tuberculosis complex sp. N0157]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMPAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T126759 NZ_CP040692:c2080828-2080418 [Mycobacterium tuberculosis complex sp. N0157]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCCCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT126759 WP_003410651.1 NZ_CP040692:c2081054-2080821 [Mycobacterium tuberculosis complex sp. N0157]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT126759 NZ_CP040692:c2081054-2080821 [Mycobacterium tuberculosis complex sp. N0157]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References