Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2037154..2037849 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FF956_RS09570 Protein ID WP_003410811.1
Coordinates 2037415..2037849 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FF956_RS09565 Protein ID WP_003410814.1
Coordinates 2037154..2037408 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS09535 (FF956_09940) 2032502..2032696 + 195 WP_003411026.1 ubiquitin-like protein Pup -
FF956_RS09540 (FF956_09945) 2032693..2033568 + 876 WP_003411023.1 proteasome subunit beta -
FF956_RS09545 (FF956_09950) 2033565..2034311 + 747 WP_003901330.1 proteasome subunit alpha -
FF956_RS09550 (FF956_09955) 2034851..2035582 - 732 WP_003903758.1 PPE family protein -
FF956_RS09555 (FF956_09960) 2035638..2035934 - 297 WP_003410820.1 PE family protein -
FF956_RS09560 (FF956_09970) 2036881..2037138 + 258 WP_003410816.1 hypothetical protein -
FF956_RS09565 (FF956_09975) 2037154..2037408 + 255 WP_003410814.1 antitoxin Antitoxin
FF956_RS09570 (FF956_09980) 2037415..2037849 + 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FF956_RS09575 (FF956_09985) 2037828..2038661 - 834 WP_003899172.1 SWIM zinc finger family protein -
FF956_RS09580 (FF956_09990) 2038654..2041683 - 3030 WP_003908805.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T126758 WP_003410811.1 NZ_CP040692:2037415-2037849 [Mycobacterium tuberculosis complex sp. N0157]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T126758 NZ_CP040692:2037415-2037849 [Mycobacterium tuberculosis complex sp. N0157]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT126758 WP_003410814.1 NZ_CP040692:2037154-2037408 [Mycobacterium tuberculosis complex sp. N0157]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT126758 NZ_CP040692:2037154-2037408 [Mycobacterium tuberculosis complex sp. N0157]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References