Detailed information of TA system TA126757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2000572..2001101
• Replicon: chromosome
• Accession: NZ_CP040692
• Organism: Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: FF956_RS09365
• Protein ID: WP_003411124.1
• Coordinates: 2000784..2001101 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: FF956_RS09360
• Protein ID: WP_003411127.1
• Coordinates: 2000572..2000787 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF956_RS09330 (FF956_09740)	1995678..1996454	+	777	WP_003903768.1	YggS family pyridoxal phosphate-dependent enzyme	-
FF956_RS09335 (FF956_09745)	1996520..1997176	+	657	WP_003411133.1	cell division protein SepF	-
FF956_RS09340 (FF956_09750)	1997338..1997628	+	291	WP_003900476.1	YggT family protein	-
FF956_RS09345 (FF956_09755)	1997896..1998678	+	783	WP_003411131.1	cell wall synthesis protein Wag31	-
FF956_RS09350 (FF956_09760)	1998773..1999129	+	357	WP_003411130.1	hypothetical protein	-
FF956_RS09355 (FF956_09765)	1999259..2000317	-	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
FF956_RS09360 (FF956_09770)	2000572..2000787	+	216	WP_003411127.1	antitoxin ParD2	Antitoxin
FF956_RS09365 (FF956_09775)	2000784..2001101	+	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF956_RS09375 (FF956_09785)	2001572..2002918	+	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
FF956_RS09380 (FF956_09790)	2002966..2003496	+	531	WP_003903767.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
FF956_RS09385 (FF956_09795)	2003501..2004574	-	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
FF956_RS09390 (FF956_09800)	2004610..2004891	-	282	WP_003411112.1	DUF5703 family protein	-
FF956_RS09395 (FF956_09805)	2004888..2005964	-	1077	WP_003907870.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T126757 WP_003411124.1 NZ_CP040692:2000784-2001101 [Mycobacterium tuberculosis complex sp. N0157]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T126757 NZ_CP040692:2000784-2001101 [Mycobacterium tuberculosis complex sp. N0157]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT126757 WP_003411127.1 NZ_CP040692:2000572-2000787 [Mycobacterium tuberculosis complex sp. N0157]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT126757 NZ_CP040692:2000572-2000787 [Mycobacterium tuberculosis complex sp. N0157]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4