Detailed information of TA system TA126755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1560100..1560740
• Replicon: chromosome
• Accession: NZ_CP040692
• Organism: Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: FF956_RS07295
• Protein ID: WP_003412970.1
• Coordinates: 1560321..1560740 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: FF956_RS07290
• Protein ID: WP_003412975.1
• Coordinates: 1560100..1560324 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF956_RS07270 (FF956_07590)	1555767..1556330	+	564	WP_003412989.1	elongation factor P	-
FF956_RS07275 (FF956_07595)	1556333..1556803	+	471	WP_003412985.1	transcription antitermination factor NusB	-
FF956_RS07280 (FF956_07600)	1556803..1557204	+	402	WP_003412981.1	hypothetical protein	-
FF956_RS07285 (FF956_07605)	1557276..1560069	+	2794	Protein_1439	amino acid decarboxylase	-
FF956_RS07290 (FF956_07610)	1560100..1560324	+	225	WP_003412975.1	antitoxin VapB39	Antitoxin
FF956_RS07295 (FF956_07615)	1560321..1560740	+	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF956_RS07300 (FF956_07620)	1560741..1561691	-	951	WP_003911916.1	ERCC4 domain-containing protein	-
FF956_RS07305	1561750..1561995	+	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FF956_RS07310 (FF956_07625)	1562336..1563256	+	921	WP_003412965.1	restriction endonuclease	-
FF956_RS07315 (FF956_07630)	1563291..1563692	-	402	WP_003412963.1	PIN domain-containing protein	-
FF956_RS07320 (FF956_07635)	1563689..1563916	-	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
FF956_RS07325 (FF956_07645)	1564433..1565155	+	723	WP_003412957.1	DUF1906 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T126755 WP_003412970.1 NZ_CP040692:1560321-1560740 [Mycobacterium tuberculosis complex sp. N0157]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T126755 NZ_CP040692:1560321-1560740 [Mycobacterium tuberculosis complex sp. N0157]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT126755 WP_003412975.1 NZ_CP040692:1560100-1560324 [Mycobacterium tuberculosis complex sp. N0157]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT126755 NZ_CP040692:1560100-1560324 [Mycobacterium tuberculosis complex sp. N0157]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09