Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | unclassified/- |
| Location | 1439172..1439820 | Replicon | chromosome |
| Accession | NZ_CP040692 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0157 | ||
Toxin (Protein)
| Gene name | novel[antitoxin] | Uniprot ID | - |
| Locus tag | FF956_RS06640 | Protein ID | WP_003903987.1 |
| Coordinates | 1439497..1439820 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
| Locus tag | FF956_RS06635 | Protein ID | WP_003899415.1 |
| Coordinates | 1439172..1439417 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF956_RS06590 (FF956_06885) | 1434320..1434553 | - | 234 | WP_003413717.1 | hypothetical protein | - |
| FF956_RS06595 (FF956_06890) | 1434652..1434924 | - | 273 | WP_003900544.1 | hypothetical protein | - |
| FF956_RS06600 (FF956_06895) | 1434830..1435219 | + | 390 | WP_003899422.1 | hypothetical protein | - |
| FF956_RS06605 (FF956_06900) | 1435216..1435443 | + | 228 | WP_003899421.1 | hypothetical protein | - |
| FF956_RS06610 (FF956_06905) | 1435588..1436715 | + | 1128 | WP_003899420.1 | site-specific integrase | - |
| FF956_RS06615 (FF956_06910) | 1436718..1437080 | + | 363 | WP_003900543.1 | hypothetical protein | - |
| FF956_RS06620 (FF956_06915) | 1437097..1437357 | + | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
| FF956_RS06625 (FF956_06920) | 1437354..1437746 | + | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
| FF956_RS06630 (FF956_06925) | 1437748..1439175 | + | 1428 | WP_003908030.1 | DUF3631 domain-containing protein | - |
| FF956_RS06635 (FF956_06930) | 1439172..1439417 | + | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
| FF956_RS06640 (FF956_06935) | 1439497..1439820 | + | 324 | WP_003903987.1 | type II toxin-antitoxin system toxin | Toxin |
| FF956_RS06645 (FF956_06940) | 1439987..1440478 | + | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
| FF956_RS06650 (FF956_06945) | 1440631..1441164 | + | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
| FF956_RS06655 (FF956_06950) | 1441172..1442611 | + | 1440 | WP_003901443.1 | phage major capsid protein | - |
| FF956_RS06660 (FF956_06955) | 1442782..1443033 | - | 252 | WP_003908028.1 | hypothetical protein | - |
| FF956_RS06665 (FF956_06960) | 1443021..1443485 | - | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
| FF956_RS06670 (FF956_06965) | 1443499..1444497 | - | 999 | WP_003908027.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1435588..1444497 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12353.82 Da Isoelectric Point: 7.4705
>T126750 WP_003903987.1 NZ_CP040692:1439497-1439820 [Mycobacterium tuberculosis complex sp. N0157]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ
Download Length: 324 bp
>T126750 NZ_CP040692:1439497-1439820 [Mycobacterium tuberculosis complex sp. N0157]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT126750 WP_003899415.1 NZ_CP040692:1439172-1439417 [Mycobacterium tuberculosis complex sp. N0157]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT126750 NZ_CP040692:1439172-1439417 [Mycobacterium tuberculosis complex sp. N0157]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|