Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 1278263..1278867 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag FF956_RS05730 Protein ID WP_003414492.1
Coordinates 1278475..1278867 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag FF956_RS05725 Protein ID WP_003414495.1
Coordinates 1278263..1278478 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS05700 (FF956_05975) 1273265..1274176 + 912 WP_003904073.1 sugar ABC transporter permease -
FF956_RS05705 (FF956_05980) 1274173..1275000 + 828 WP_003904072.1 carbohydrate ABC transporter permease -
FF956_RS05710 (FF956_05985) 1275003..1276313 + 1311 WP_003414501.1 ABC transporter substrate-binding protein -
FF956_RS05715 (FF956_05990) 1276306..1277388 + 1083 WP_003908076.1 ABC transporter ATP-binding protein -
FF956_RS05720 (FF956_05995) 1277467..1278216 - 750 WP_003908075.1 enoyl-CoA hydratase -
FF956_RS05725 (FF956_06000) 1278263..1278478 + 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FF956_RS05730 (FF956_06005) 1278475..1278867 + 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
FF956_RS05735 (FF956_06010) 1278888..1279157 + 270 WP_003414489.1 DUF2277 family protein -
FF956_RS05740 (FF956_06015) 1279154..1279699 + 546 WP_003908074.1 DUF1802 family protein -
FF956_RS05745 (FF956_06020) 1280004..1280891 + 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
FF956_RS05750 (FF956_06025) 1280894..1281778 + 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FF956_RS05755 (FF956_06030) 1282050..1282595 + 546 WP_003904931.1 DUF1802 family protein -
FF956_RS05760 (FF956_06035) 1282929..1283717 + 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T126745 WP_003414492.1 NZ_CP040692:1278475-1278867 [Mycobacterium tuberculosis complex sp. N0157]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T126745 NZ_CP040692:1278475-1278867 [Mycobacterium tuberculosis complex sp. N0157]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT126745 WP_003414495.1 NZ_CP040692:1278263-1278478 [Mycobacterium tuberculosis complex sp. N0157]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT126745 NZ_CP040692:1278263-1278478 [Mycobacterium tuberculosis complex sp. N0157]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References