Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1237402..1237950 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag FF956_RS05530 Protein ID WP_003414602.1
Coordinates 1237402..1237665 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag FF956_RS05535 Protein ID WP_003414599.1
Coordinates 1237669..1237950 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS05510 (FF956_05780) 1232476..1233717 + 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
FF956_RS05515 (FF956_05785) 1233725..1234939 + 1215 WP_003414610.1 zinc metalloprotease Rip -
FF956_RS05520 (FF956_05790) 1234956..1236119 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
FF956_RS05525 (FF956_05795) 1236175..1237029 + 855 WP_003899516.1 GNAT family N-acetyltransferase -
FF956_RS05530 (FF956_05800) 1237402..1237665 - 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FF956_RS05535 (FF956_05805) 1237669..1237950 - 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
FF956_RS05540 (FF956_05810) 1238222..1240033 + 1812 WP_003414596.1 penicillin-binding protein -
FF956_RS05545 (FF956_05815) 1240115..1240495 - 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
FF956_RS05550 (FF956_05820) 1240492..1240740 - 249 WP_003913411.1 antitoxin VapB23 -
FF956_RS05555 (FF956_05825) 1240844..1241428 + 585 WP_003414585.1 DUF1707 domain-containing protein -
FF956_RS05560 (FF956_05830) 1241470..1242327 + 858 WP_003899513.1 type I methionyl aminopeptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T126744 WP_003414602.1 NZ_CP040692:c1237665-1237402 [Mycobacterium tuberculosis complex sp. N0157]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T126744 NZ_CP040692:c1237665-1237402 [Mycobacterium tuberculosis complex sp. N0157]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT126744 WP_003414599.1 NZ_CP040692:c1237950-1237669 [Mycobacterium tuberculosis complex sp. N0157]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT126744 NZ_CP040692:c1237950-1237669 [Mycobacterium tuberculosis complex sp. N0157]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3G5O


Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References