Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 643909..644438 | Replicon | chromosome |
| Accession | NZ_CP040692 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0157 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | FF956_RS02955 | Protein ID | WP_003417760.1 |
| Coordinates | 643909..644166 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | FF956_RS02960 | Protein ID | WP_003417757.1 |
| Coordinates | 644163..644438 (-) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF956_RS02925 (FF956_03075) | 640337..640729 | + | 393 | WP_003417776.1 | serine protease inhibitor | - |
| FF956_RS02930 (FF956_03080) | 640707..641075 | + | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| FF956_RS02935 (FF956_03085) | 641056..641637 | + | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| FF956_RS02940 (FF956_03090) | 641644..642195 | + | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| FF956_RS02945 (FF956_03095) | 642192..642560 | - | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| FF956_RS02950 (FF956_03100) | 642677..643867 | - | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| FF956_RS02955 (FF956_03105) | 643909..644166 | - | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| FF956_RS02960 (FF956_03110) | 644163..644438 | - | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| FF956_RS02965 (FF956_03115) | 644562..645407 | + | 846 | WP_003905054.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| FF956_RS02970 (FF956_03120) | 645404..645697 | + | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| FF956_RS02975 (FF956_03125) | 645711..646100 | - | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| FF956_RS02980 (FF956_03130) | 646215..646475 | + | 261 | WP_003417741.1 | hypothetical protein | - |
| FF956_RS02985 (FF956_03140) | 646502..646989 | + | 488 | Protein_588 | FAD-binding protein | - |
| FF956_RS02990 (FF956_03145) | 647176..647865 | + | 690 | WP_003917774.1 | BBE domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T126740 WP_003417760.1 NZ_CP040692:c644166-643909 [Mycobacterium tuberculosis complex sp. N0157]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T126740 NZ_CP040692:c644166-643909 [Mycobacterium tuberculosis complex sp. N0157]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT126740 WP_003417757.1 NZ_CP040692:c644438-644163 [Mycobacterium tuberculosis complex sp. N0157]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT126740 NZ_CP040692:c644438-644163 [Mycobacterium tuberculosis complex sp. N0157]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|