Detailed information of TA system TA126738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 589655..590340
• Replicon: chromosome
• Accession: NZ_CP040692
• Organism: Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: FF956_RS02715
• Protein ID: WP_003417998.1
• Coordinates: 589655..590065 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FF956_RS02720
• Protein ID: WP_003912220.1
• Coordinates: 590062..590340 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF956_RS02700 (FF956_02840)	585094..586683	+	1590	WP_003900682.1	IMP dehydrogenase	-
FF956_RS02705 (FF956_02845)	586703..587830	+	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
FF956_RS02710 (FF956_02850)	587886..589622	+	1737	WP_003418002.1	cholesterol oxidase	-
FF956_RS02715 (FF956_02855)	589655..590065	-	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF956_RS02720 (FF956_02860)	590062..590340	-	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF956_RS02725 (FF956_02865)	590396..591283	-	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
FF956_RS02730 (FF956_02870)	591345..591911	+	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
FF956_RS02735 (FF956_02875)	592029..592733	+	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
FF956_RS02740 (FF956_02880)	592750..594351	+	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T126738 WP_003417998.1 NZ_CP040692:c590065-589655 [Mycobacterium tuberculosis complex sp. N0157]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T126738 NZ_CP040692:c590065-589655 [Mycobacterium tuberculosis complex sp. N0157]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT126738 WP_003912220.1 NZ_CP040692:c590340-590062 [Mycobacterium tuberculosis complex sp. N0157]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT126738 NZ_CP040692:c590340-590062 [Mycobacterium tuberculosis complex sp. N0157]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: G0TIR9