Detailed information of TA system TA126737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3826423..3827108
• Replicon: chromosome
• Accession: NZ_CP040691
• Organism: Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: FF955_RS17995
• Protein ID: WP_003417998.1
• Coordinates: 3826698..3827108 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FF955_RS17990
• Protein ID: WP_180895138.1
• Coordinates: 3826423..3826701 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF955_RS17970 (FF955_18650)	3822412..3824013	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
FF955_RS17975 (FF955_18655)	3824030..3824734	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
FF955_RS17980 (FF955_18660)	3824852..3825418	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
FF955_RS17985 (FF955_18665)	3825480..3826367	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
FF955_RS17990 (FF955_18670)	3826423..3826701	+	279	WP_180895138.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF955_RS17995 (FF955_18675)	3826698..3827108	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF955_RS18000 (FF955_18680)	3827141..3828877	-	1737	WP_003418002.1	cholesterol oxidase	-
FF955_RS18005 (FF955_18685)	3828933..3830060	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
FF955_RS18010 (FF955_18690)	3830080..3831669	-	1590	WP_003901630.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-58)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T126737 WP_003417998.1 NZ_CP040691:3826698-3827108 [Mycobacterium tuberculosis complex sp. N0155]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T126737 NZ_CP040691:3826698-3827108 [Mycobacterium tuberculosis complex sp. N0155]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10227.70 Da
• Isoelectric Point: 8.0222

>AT126737 WP_180895138.1 NZ_CP040691:3826423-3826701 [Mycobacterium tuberculosis complex sp. N0155]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT126737 NZ_CP040691:3826423-3826701 [Mycobacterium tuberculosis complex sp. N0155]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCTGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: G0TIR9