Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770294..3770823 Replicon chromosome
Accession NZ_CP040691
Organism Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FF955_RS17730 Protein ID WP_003417760.1
Coordinates 3770566..3770823 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FF955_RS17725 Protein ID WP_003417757.1
Coordinates 3770294..3770569 (+) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF955_RS17690 (FF955_18365) 3766867..3767556 - 690 WP_003917774.1 BBE domain-containing protein -
FF955_RS17695 (FF955_18370) 3767743..3768114 - 372 WP_003417739.1 FAD-binding protein -
FF955_RS17700 3768012..3768230 - 219 WP_157132559.1 hypothetical protein -
FF955_RS17705 (FF955_18380) 3768257..3768517 - 261 WP_003417741.1 hypothetical protein -
FF955_RS17710 (FF955_18385) 3768632..3769021 + 390 WP_003417745.1 DUF732 domain-containing protein -
FF955_RS17715 (FF955_18390) 3769035..3769328 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FF955_RS17720 (FF955_18395) 3769325..3770170 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FF955_RS17725 (FF955_18400) 3770294..3770569 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FF955_RS17730 (FF955_18405) 3770566..3770823 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FF955_RS17735 (FF955_18410) 3770865..3772055 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FF955_RS17740 (FF955_18415) 3772172..3772540 + 369 WP_003417765.1 FHA domain-containing protein -
FF955_RS17745 (FF955_18420) 3772537..3773088 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FF955_RS17750 (FF955_18425) 3773095..3773676 - 582 WP_003417769.1 ATP/GTP-binding protein -
FF955_RS17755 (FF955_18430) 3773657..3774025 - 369 WP_003417772.1 DUF742 domain-containing protein -
FF955_RS17760 (FF955_18435) 3774003..3774395 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-85)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T126735 WP_003417760.1 NZ_CP040691:3770566-3770823 [Mycobacterium tuberculosis complex sp. N0155]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T126735 NZ_CP040691:3770566-3770823 [Mycobacterium tuberculosis complex sp. N0155]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT126735 WP_003417757.1 NZ_CP040691:3770294-3770569 [Mycobacterium tuberculosis complex sp. N0155]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT126735 NZ_CP040691:3770294-3770569 [Mycobacterium tuberculosis complex sp. N0155]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3OEI


Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References