Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2864189..2864826 | Replicon | chromosome |
| Accession | NZ_CP040691 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0155 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P0DMV7 |
| Locus tag | FF955_RS13455 | Protein ID | WP_003413180.1 |
| Coordinates | 2864189..2864584 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ44 |
| Locus tag | FF955_RS13460 | Protein ID | WP_003413183.1 |
| Coordinates | 2864581..2864826 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF955_RS13415 (FF955_13890) | 2859593..2860804 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| FF955_RS13420 (FF955_13900) | 2860931..2861590 | + | 660 | WP_003902296.1 | LppA family lipoprotein | - |
| FF955_RS13425 (FF955_13905) | 2861587..2862249 | + | 663 | WP_003905878.1 | LppA family lipoprotein | - |
| FF955_RS13430 (FF955_13910) | 2862246..2862523 | + | 278 | Protein_2651 | type II toxin-antitoxin system VapB family antitoxin | - |
| FF955_RS13435 (FF955_13915) | 2862616..2863029 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
| FF955_RS13440 (FF955_13920) | 2863068..2863325 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | - |
| FF955_RS13445 (FF955_13925) | 2863322..2863699 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF955_RS13450 (FF955_13930) | 2863715..2864089 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| FF955_RS13455 (FF955_13935) | 2864189..2864584 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | Toxin |
| FF955_RS13460 (FF955_13940) | 2864581..2864826 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | Antitoxin |
| FF955_RS13465 (FF955_13950) | 2865237..2865656 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| FF955_RS13470 (FF955_13955) | 2865668..2866477 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| FF955_RS13475 (FF955_13960) | 2866474..2867727 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| FF955_RS13480 (FF955_13965) | 2867720..2868232 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14619.53 Da Isoelectric Point: 6.9794
>T126723 WP_003413180.1 NZ_CP040691:c2864584-2864189 [Mycobacterium tuberculosis complex sp. N0155]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
Download Length: 396 bp
>T126723 NZ_CP040691:c2864584-2864189 [Mycobacterium tuberculosis complex sp. N0155]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
Antitoxin
Download Length: 82 a.a. Molecular weight: 9098.33 Da Isoelectric Point: 5.6007
>AT126723 WP_003413183.1 NZ_CP040691:c2864826-2864581 [Mycobacterium tuberculosis complex sp. N0155]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
Download Length: 246 bp
>AT126723 NZ_CP040691:c2864826-2864581 [Mycobacterium tuberculosis complex sp. N0155]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 5WZ4 | |
| PDB | 5WZF |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BW31 |