126719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2802551..2803203 Replicon chromosome
Accession NZ_CP040691
Organism Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag FF955_RS13155 Protein ID WP_003905869.1
Coordinates 2802778..2803203 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FF955_RS13150 Protein ID WP_003412749.1
Coordinates 2802551..2802772 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF955_RS13135 (FF955_13580) 2800791..2800997 - 207 WP_003899347.1 hypothetical protein -
FF955_RS13140 (FF955_13585) 2801133..2801756 + 624 WP_003900858.1 TIGR00725 family protein -
FF955_RS13145 (FF955_13590) 2801746..2802498 + 753 WP_003901416.1 hypothetical protein -
FF955_RS13150 (FF955_13595) 2802551..2802772 + 222 WP_003412749.1 antitoxin Antitoxin
FF955_RS13155 (FF955_13600) 2802778..2803203 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
FF955_RS13160 (FF955_13605) 2803226..2804407 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
FF955_RS13165 (FF955_13610) 2804404..2805450 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FF955_RS13170 (FF955_13615) 2805461..2806564 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FF955_RS13175 (FF955_13620) 2806823..2807644 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FF955_RS13180 (FF955_13625) 2807641..2808198 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T126719 WP_003905869.1 NZ_CP040691:2802778-2803203 [Mycobacterium tuberculosis complex sp. N0155]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T126719 NZ_CP040691:2802778-2803203 [Mycobacterium tuberculosis complex sp. N0155]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT126719 WP_003412749.1 NZ_CP040691:2802551-2802772 [Mycobacterium tuberculosis complex sp. N0155]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT126719 NZ_CP040691:2802551-2802772 [Mycobacterium tuberculosis complex sp. N0155]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References