Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 2249228..2249854 | Replicon | chromosome |
Accession | NZ_CP040691 | ||
Organism | Mycobacterium tuberculosis complex sp. N0155 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P64926 |
Locus tag | FF955_RS10540 | Protein ID | WP_003410075.1 |
Coordinates | 2249456..2249854 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A806JLL8 |
Locus tag | FF955_RS10535 | Protein ID | WP_003911750.1 |
Coordinates | 2249228..2249455 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FF955_RS10525 (FF955_10895) | 2247267..2247611 | - | 345 | WP_003410065.1 | ferredoxin family protein | - |
FF955_RS10530 (FF955_10900) | 2247800..2248969 | - | 1170 | WP_003899126.1 | ATP-binding protein | - |
FF955_RS10535 (FF955_10905) | 2249228..2249455 | + | 228 | WP_003911750.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
FF955_RS10540 (FF955_10910) | 2249456..2249854 | + | 399 | WP_003410075.1 | PIN domain nuclease | Toxin |
FF955_RS10545 (FF955_10915) | 2250037..2250468 | - | 432 | WP_003410078.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
FF955_RS10550 (FF955_10920) | 2250569..2251003 | + | 435 | WP_003914358.1 | DUF1398 domain-containing protein | - |
FF955_RS10555 (FF955_10935) | 2251440..2251619 | - | 180 | Protein_2086 | hypothetical protein | - |
FF955_RS10560 (FF955_10940) | 2251707..2252327 | + | 621 | WP_003410086.1 | IS110 family transposase | - |
FF955_RS10565 (FF955_10945) | 2252281..2252871 | + | 591 | WP_003899131.1 | IS110 family transposase | - |
FF955_RS10570 (FF955_10950) | 2252999..2254255 | - | 1257 | WP_003902247.1 | HNH endonuclease signature motif containing protein | - |
FF955_RS10575 (FF955_10960) | 2254609..2254809 | + | 201 | Protein_2090 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14731.02 Da Isoelectric Point: 6.7067
>T126714 WP_003410075.1 NZ_CP040691:2249456-2249854 [Mycobacterium tuberculosis complex sp. N0155]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF
Download Length: 399 bp
>T126714 NZ_CP040691:2249456-2249854 [Mycobacterium tuberculosis complex sp. N0155]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8346.16 Da Isoelectric Point: 4.1621
>AT126714 WP_003911750.1 NZ_CP040691:2249228-2249455 [Mycobacterium tuberculosis complex sp. N0155]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES
Download Length: 228 bp
>AT126714 NZ_CP040691:2249228-2249455 [Mycobacterium tuberculosis complex sp. N0155]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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