126713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2225489..2226075 Replicon chromosome
Accession NZ_CP040691
Organism Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag FF955_RS10435 Protein ID WP_003410010.1
Coordinates 2225489..2225833 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag FF955_RS10440 Protein ID WP_003410014.1
Coordinates 2225827..2226075 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF955_RS10400 (FF955_10770) 2221195..2221794 + 600 WP_003910883.1 L-lysine exporter -
FF955_RS10405 (FF955_10775) 2222210..2222638 + 429 WP_003409992.1 cellulose-binding protein -
FF955_RS10410 (FF955_10780) 2222864..2223403 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FF955_RS10415 (FF955_10790) 2223923..2224483 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
FF955_RS10420 (FF955_10795) 2224480..2224821 - 342 WP_003410003.1 DUF2384 domain-containing protein -
FF955_RS10425 (FF955_10800) 2224907..2225164 + 258 WP_003410006.1 hypothetical protein -
FF955_RS10430 (FF955_10805) 2225065..2225400 - 336 WP_003410009.1 dehydrogenase -
FF955_RS10435 (FF955_10810) 2225489..2225833 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
FF955_RS10440 (FF955_10815) 2225827..2226075 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
FF955_RS10445 (FF955_10820) 2226175..2228490 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FF955_RS10450 (FF955_10825) 2228487..2228759 - 273 WP_003410017.1 DUF1490 family protein -
FF955_RS10455 (FF955_10830) 2228812..2229168 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
FF955_RS10460 (FF955_10835) 2229325..2230092 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T126713 WP_003410010.1 NZ_CP040691:c2225833-2225489 [Mycobacterium tuberculosis complex sp. N0155]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T126713 NZ_CP040691:c2225833-2225489 [Mycobacterium tuberculosis complex sp. N0155]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT126713 WP_003410014.1 NZ_CP040691:c2226075-2225827 [Mycobacterium tuberculosis complex sp. N0155]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT126713 NZ_CP040691:c2226075-2225827 [Mycobacterium tuberculosis complex sp. N0155]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References