Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2190369..2190913 | Replicon | chromosome |
| Accession | NZ_CP040691 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0155 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FF955_RS10215 | Protein ID | WP_003409896.1 |
| Coordinates | 2190369..2190665 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FF955_RS10220 | Protein ID | WP_003409899.1 |
| Coordinates | 2190662..2190913 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF955_RS10160 (FF955_10515) | 2185402..2185752 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FF955_RS10165 (FF955_10520) | 2185763..2186665 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FF955_RS10170 (FF955_10525) | 2186686..2186877 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FF955_RS10175 (FF955_10530) | 2186878..2187174 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FF955_RS10180 (FF955_10535) | 2187414..2187629 | + | 216 | WP_003409878.1 | antitoxin | - |
| FF955_RS10185 (FF955_10540) | 2187626..2187937 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF955_RS10190 | 2187911..2188432 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FF955_RS10195 (FF955_10550) | 2188407..2188784 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FF955_RS10200 (FF955_10555) | 2188826..2189275 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FF955_RS10205 (FF955_10560) | 2189272..2189817 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FF955_RS10210 (FF955_10565) | 2189706..2190320 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FF955_RS10215 (FF955_10570) | 2190369..2190665 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FF955_RS10220 (FF955_10575) | 2190662..2190913 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FF955_RS10225 (FF955_10580) | 2190900..2191394 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FF955_RS10230 (FF955_10585) | 2191554..2191961 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF955_RS10235 (FF955_10590) | 2191965..2192237 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FF955_RS10240 (FF955_10595) | 2192270..2193490 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FF955_RS10245 (FF955_10610) | 2194389..2195186 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T126710 WP_003409896.1 NZ_CP040691:c2190665-2190369 [Mycobacterium tuberculosis complex sp. N0155]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T126710 NZ_CP040691:c2190665-2190369 [Mycobacterium tuberculosis complex sp. N0155]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT126710 WP_003409899.1 NZ_CP040691:c2190913-2190662 [Mycobacterium tuberculosis complex sp. N0155]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT126710 NZ_CP040691:c2190913-2190662 [Mycobacterium tuberculosis complex sp. N0155]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |