126707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1962313..1962773 Replicon chromosome
Accession NZ_CP040691
Organism Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag FF955_RS09155 Protein ID WP_003898996.1
Coordinates 1962525..1962773 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag FF955_RS09150 Protein ID WP_003408528.1
Coordinates 1962313..1962525 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF955_RS09135 (FF955_09430) 1958791..1959978 - 1188 WP_003898992.1 nitrate transporter NarK -
FF955_RS09140 (FF955_09435) 1960265..1960549 + 285 WP_003408522.1 DUF1876 domain-containing protein -
FF955_RS09145 (FF955_09440) 1960563..1962245 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
FF955_RS09150 (FF955_09445) 1962313..1962525 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF955_RS09155 (FF955_09450) 1962525..1962773 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
FF955_RS09160 (FF955_09455) 1962781..1963518 + 738 WP_003898997.1 hypothetical protein -
FF955_RS09165 (FF955_09460) 1963612..1965312 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
FF955_RS09170 (FF955_09465) 1965597..1965998 - 402 WP_003408538.1 hypothetical protein -
FF955_RS09175 (FF955_09470) 1965988..1966599 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T126707 WP_003898996.1 NZ_CP040691:1962525-1962773 [Mycobacterium tuberculosis complex sp. N0155]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T126707 NZ_CP040691:1962525-1962773 [Mycobacterium tuberculosis complex sp. N0155]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT126707 WP_003408528.1 NZ_CP040691:1962313-1962525 [Mycobacterium tuberculosis complex sp. N0155]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT126707 NZ_CP040691:1962313-1962525 [Mycobacterium tuberculosis complex sp. N0155]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References