Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1941432..1942045 Replicon chromosome
Accession NZ_CP040691
Organism Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag FF955_RS09040 Protein ID WP_003408465.1
Coordinates 1941432..1941821 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag FF955_RS09045 Protein ID WP_003408469.1
Coordinates 1941818..1942045 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF955_RS09005 (FF955_09300) 1937061..1937975 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
FF955_RS09010 (FF955_09305) 1937978..1938808 + 831 WP_003408448.1 cyclase family protein -
FF955_RS09015 (FF955_09310) 1938808..1939158 + 351 WP_003898986.1 cupin domain-containing protein -
FF955_RS09020 (FF955_09315) 1939211..1940029 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
FF955_RS09025 (FF955_09320) 1940043..1940822 + 780 WP_003408460.1 IclR family transcriptional regulator -
FF955_RS09035 1941253..1941384 + 132 Protein_1782 IS3 family transposase -
FF955_RS09040 (FF955_09330) 1941432..1941821 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
FF955_RS09045 (FF955_09335) 1941818..1942045 - 228 WP_003408469.1 antitoxin Antitoxin
FF955_RS09050 (FF955_09340) 1942263..1943747 + 1485 WP_003408473.1 biotin carboxylase -
FF955_RS09055 (FF955_09345) 1943744..1944991 + 1248 WP_003408476.1 serine hydrolase -
FF955_RS09060 (FF955_09350) 1945034..1945453 - 420 WP_003408483.1 hypothetical protein -
FF955_RS09065 (FF955_09355) 1945443..1946153 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T126706 WP_003408465.1 NZ_CP040691:c1941821-1941432 [Mycobacterium tuberculosis complex sp. N0155]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T126706 NZ_CP040691:c1941821-1941432 [Mycobacterium tuberculosis complex sp. N0155]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT126706 WP_003408469.1 NZ_CP040691:c1942045-1941818 [Mycobacterium tuberculosis complex sp. N0155]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT126706 NZ_CP040691:c1942045-1941818 [Mycobacterium tuberculosis complex sp. N0155]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References