Detailed information of TA system TA126705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1768388..1769001
• Replicon: chromosome
• Accession: NZ_CP040691
• Organism: Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FF955_RS08290
• Protein ID: WP_003905593.1
• Coordinates: 1768597..1769001 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E8UJ46
• Locus tag: FF955_RS08285
• Protein ID: WP_009935474.1
• Coordinates: 1768388..1768591 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF955_RS08255 (FF955_08535)	1763793..1764173	+	381	WP_003407768.1	fumarate reductase subunit C	-
FF955_RS08260 (FF955_08540)	1764170..1764547	+	378	WP_003407771.1	fumarate reductase subunit FrdD	-
FF955_RS08265 (FF955_08545)	1764615..1765223	+	609	WP_003407773.1	TetR/AcrR family transcriptional regulator	-
FF955_RS08270 (FF955_08550)	1765407..1766555	+	1149	Protein_1631	MMPL family transporter	-
FF955_RS08275 (FF955_08555)	1766565..1767011	+	447	WP_003407780.1	F420H(2)-dependent quinone reductase	-
FF955_RS08280 (FF955_08560)	1767046..1768335	+	1290	WP_003407781.1	threonine ammonia-lyase	-
FF955_RS08285 (FF955_08565)	1768388..1768591	+	204	WP_009935474.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FF955_RS08290 (FF955_08570)	1768597..1769001	+	405	WP_003905593.1	type II toxin-antitoxin system toxin ribonuclease VapC11	Toxin
FF955_RS08295 (FF955_08575)	1769018..1770760	-	1743	WP_003407788.1	malto-oligosyltrehalose trehalohydrolase	-
FF955_RS08300 (FF955_08580)	1770753..1773050	-	2298	WP_003407790.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14636.74 Da
• Isoelectric Point: 5.6587

>T126705 WP_003905593.1 NZ_CP040691:1768597-1769001 [Mycobacterium tuberculosis complex sp. N0155]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARVTNLQAASFR

Nucleotide

• Length: 405 bp

>T126705 NZ_CP040691:1768597-1769001 [Mycobacterium tuberculosis complex sp. N0155]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGGTTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7501.48 Da
• Isoelectric Point: 4.3951

>AT126705 WP_009935474.1 NZ_CP040691:1768388-1768591 [Mycobacterium tuberculosis complex sp. N0155]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Nucleotide

• Length: 204 bp

>AT126705 NZ_CP040691:1768388-1768591 [Mycobacterium tuberculosis complex sp. N0155]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E8UJ46