Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 1238386..1238954 | Replicon | chromosome |
Accession | NZ_CP040691 | ||
Organism | Mycobacterium tuberculosis complex sp. N0155 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TH08 |
Locus tag | FF955_RS05930 | Protein ID | WP_003405865.1 |
Coordinates | 1238580..1238954 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TH07 |
Locus tag | FF955_RS05925 | Protein ID | WP_003405863.1 |
Coordinates | 1238386..1238583 (+) | Length | 66 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FF955_RS05905 (FF955_06075) | 1234427..1235065 | - | 639 | WP_003898730.1 | lipid droplet-associated protein | - |
FF955_RS05910 (FF955_06080) | 1235155..1236162 | + | 1008 | WP_003405853.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
FF955_RS05915 (FF955_06085) | 1236179..1237162 | - | 984 | WP_003898731.1 | hypothetical protein | - |
FF955_RS05920 (FF955_06090) | 1237225..1238298 | + | 1074 | WP_003898732.1 | redox-regulated ATPase YchF | - |
FF955_RS05925 (FF955_06095) | 1238386..1238583 | + | 198 | WP_003405863.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
FF955_RS05930 (FF955_06100) | 1238580..1238954 | + | 375 | WP_003405865.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FF955_RS05935 (FF955_06105) | 1239157..1239855 | + | 699 | WP_003898733.1 | hypothetical protein | - |
FF955_RS05940 (FF955_06110) | 1239973..1240158 | + | 186 | WP_003901093.1 | hypothetical protein | - |
FF955_RS05945 (FF955_06115) | 1240085..1240360 | - | 276 | WP_003405867.1 | hypothetical protein | - |
FF955_RS05950 (FF955_06120) | 1240603..1240926 | + | 324 | WP_003405871.1 | putative quinol monooxygenase | - |
FF955_RS05955 (FF955_06125) | 1240941..1241639 | - | 699 | WP_031646953.1 | hypothetical protein | - |
FF955_RS05960 | 1241673..1241882 | + | 210 | WP_003911400.1 | hypothetical protein | - |
FF955_RS05965 (FF955_06130) | 1241834..1242604 | - | 771 | Protein_1175 | adenylate/guanylate cyclase domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13444.56 Da Isoelectric Point: 5.1881
>T126699 WP_003405865.1 NZ_CP040691:1238580-1238954 [Mycobacterium tuberculosis complex sp. N0155]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS
Download Length: 375 bp
>T126699 NZ_CP040691:1238580-1238954 [Mycobacterium tuberculosis complex sp. N0155]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
Antitoxin
Download Length: 66 a.a. Molecular weight: 6973.03 Da Isoelectric Point: 11.7327
>AT126699 WP_003405863.1 NZ_CP040691:1238386-1238583 [Mycobacterium tuberculosis complex sp. N0155]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
Download Length: 198 bp
>AT126699 NZ_CP040691:1238386-1238583 [Mycobacterium tuberculosis complex sp. N0155]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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