126698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1229630..1230261 Replicon chromosome
Accession NZ_CP040691
Organism Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FF955_RS05875 Protein ID WP_003405820.1
Coordinates 1229630..1229941 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FF955_RS05880 Protein ID WP_003405836.1
Coordinates 1229941..1230261 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF955_RS05855 (FF955_06025) 1225111..1226535 - 1425 WP_003405805.1 class II fumarate hydratase -
FF955_RS05860 (FF955_06030) 1226566..1227654 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
FF955_RS05865 (FF955_06035) 1227710..1228354 + 645 WP_003915494.1 DUF4245 domain-containing protein -
FF955_RS05870 (FF955_06040) 1228361..1229518 - 1158 WP_003898727.1 AI-2E family transporter -
FF955_RS05875 (FF955_06045) 1229630..1229941 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FF955_RS05880 (FF955_06050) 1229941..1230261 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FF955_RS05885 (FF955_06055) 1230271..1231807 + 1537 Protein_1159 carboxylesterase/lipase family protein -
FF955_RS05890 (FF955_06060) 1231814..1232926 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FF955_RS05895 (FF955_06065) 1232936..1233193 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FF955_RS05900 (FF955_06070) 1233183..1234430 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FF955_RS05905 (FF955_06075) 1234427..1235065 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T126698 WP_003405820.1 NZ_CP040691:c1229941-1229630 [Mycobacterium tuberculosis complex sp. N0155]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T126698 NZ_CP040691:c1229941-1229630 [Mycobacterium tuberculosis complex sp. N0155]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT126698 WP_003405836.1 NZ_CP040691:c1230261-1229941 [Mycobacterium tuberculosis complex sp. N0155]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT126698 NZ_CP040691:c1230261-1229941 [Mycobacterium tuberculosis complex sp. N0155]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References