Detailed information of TA system TA126690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 716598..717262
• Replicon: chromosome
• Accession: NZ_CP040691
• Organism: Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P96917
• Locus tag: FF955_RS03285
• Protein ID: WP_003403246.1
• Coordinates: 716855..717262 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WF18
• Locus tag: FF955_RS03280
• Protein ID: WP_003403244.1
• Coordinates: 716598..716858 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF955_RS03255 (FF955_03325)	712775..713839	+	1065	WP_003898532.1	zinc ribbon domain-containing protein	-
FF955_RS03260 (FF955_03330)	713943..714890	+	948	WP_003403232.1	DUF732 domain-containing protein	-
FF955_RS03265 (FF955_03335)	714983..715237	+	255	WP_003403235.1	type II toxin-antitoxin system antitoxin VapB30	-
FF955_RS03270 (FF955_03340)	715237..715632	+	396	WP_003403236.1	type II toxin-antitoxin system toxin ribonuclease C30	-
FF955_RS03275 (FF955_03345)	715726..716466	-	741	WP_003403239.1	TVP38/TMEM64 family protein	-
FF955_RS03280 (FF955_03350)	716598..716858	+	261	WP_003403244.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF955_RS03285 (FF955_03355)	716855..717262	+	408	WP_003403246.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF955_RS03290 (FF955_03360)	717334..718485	-	1152	WP_003403248.1	FIST N-terminal domain-containing protein	-
FF955_RS03295 (FF955_03365)	718578..720305	-	1728	WP_003901883.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14376.37 Da
• Isoelectric Point: 4.3568

>T126690 WP_003403246.1 NZ_CP040691:716855-717262 [Mycobacterium tuberculosis complex sp. N0155]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Nucleotide

• Length: 408 bp

>T126690 NZ_CP040691:716855-717262 [Mycobacterium tuberculosis complex sp. N0155]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9492.84 Da
• Isoelectric Point: 11.9108

>AT126690 WP_003403244.1 NZ_CP040691:716598-716858 [Mycobacterium tuberculosis complex sp. N0155]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Nucleotide

• Length: 261 bp

>AT126690 NZ_CP040691:716598-716858 [Mycobacterium tuberculosis complex sp. N0155]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Toxin

• PDB: 3DBO

Antitoxin

• AlphaFold DB: A0A7U4BSE4