Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709355..709980 Replicon chromosome
Accession NZ_CP040691
Organism Mycobacterium tuberculosis complex sp. N0155

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FF955_RS03235 Protein ID WP_003403218.1
Coordinates 709579..709980 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FF955_RS03230 Protein ID WP_003403213.1
Coordinates 709355..709582 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF955_RS03205 (FF955_03265) 704534..704755 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FF955_RS03210 (FF955_03270) 704897..705502 + 606 WP_003898526.1 hypothetical protein -
FF955_RS03215 (FF955_03275) 705521..708088 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
FF955_RS03220 (FF955_03280) 708172..708921 + 750 WP_003898528.1 hypothetical protein -
FF955_RS03225 (FF955_03285) 708918..709160 + 243 WP_003403210.1 hypothetical protein -
FF955_RS03230 (FF955_03295) 709355..709582 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FF955_RS03235 (FF955_03300) 709579..709980 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FF955_RS03240 710109..710192 + 84 Protein_642 galactose-1-phosphate uridylyltransferase -
FF955_RS03245 710211..711292 + 1082 Protein_643 galactose-1-phosphate uridylyltransferase -
FF955_RS03250 (FF955_03315) 711289..712380 + 1092 WP_003900977.1 galactokinase -
FF955_RS03255 (FF955_03325) 712775..713839 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
FF955_RS03260 (FF955_03330) 713943..714890 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T126688 WP_003403218.1 NZ_CP040691:709579-709980 [Mycobacterium tuberculosis complex sp. N0155]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T126688 NZ_CP040691:709579-709980 [Mycobacterium tuberculosis complex sp. N0155]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT126688 WP_003403213.1 NZ_CP040691:709355-709582 [Mycobacterium tuberculosis complex sp. N0155]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT126688 NZ_CP040691:709355-709582 [Mycobacterium tuberculosis complex sp. N0155]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References