Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3763476..3764005 Replicon chromosome
Accession NZ_CP040690
Organism Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FF954_RS17660 Protein ID WP_003417760.1
Coordinates 3763748..3764005 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FF954_RS17655 Protein ID WP_003417757.1
Coordinates 3763476..3763751 (+) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF954_RS17620 (FF954_18255) 3760049..3760738 - 690 WP_003917774.1 BBE domain-containing protein -
FF954_RS17625 (FF954_18260) 3760925..3761296 - 372 WP_003417739.1 FAD-binding protein -
FF954_RS17630 3761194..3761412 - 219 WP_157132559.1 hypothetical protein -
FF954_RS17635 (FF954_18270) 3761439..3761699 - 261 WP_003417741.1 hypothetical protein -
FF954_RS17640 (FF954_18275) 3761814..3762203 + 390 WP_003417745.1 DUF732 domain-containing protein -
FF954_RS17645 (FF954_18280) 3762217..3762510 - 294 WP_031663850.1 DUF3017 domain-containing protein -
FF954_RS17650 (FF954_18285) 3762507..3763352 - 846 WP_003905054.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FF954_RS17655 (FF954_18290) 3763476..3763751 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FF954_RS17660 (FF954_18295) 3763748..3764005 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FF954_RS17665 (FF954_18300) 3764047..3765237 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FF954_RS17670 (FF954_18305) 3765354..3765722 + 369 WP_003417765.1 FHA domain-containing protein -
FF954_RS17675 (FF954_18310) 3765719..3766270 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FF954_RS17680 (FF954_18315) 3766277..3766858 - 582 WP_031662192.1 ATP/GTP-binding protein -
FF954_RS17685 (FF954_18320) 3766839..3767207 - 369 WP_003417772.1 DUF742 domain-containing protein -
FF954_RS17690 (FF954_18325) 3767185..3767577 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-85)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T126675 WP_003417760.1 NZ_CP040690:3763748-3764005 [Mycobacterium tuberculosis complex sp. N0153]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T126675 NZ_CP040690:3763748-3764005 [Mycobacterium tuberculosis complex sp. N0153]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT126675 WP_003417757.1 NZ_CP040690:3763476-3763751 [Mycobacterium tuberculosis complex sp. N0153]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT126675 NZ_CP040690:3763476-3763751 [Mycobacterium tuberculosis complex sp. N0153]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3OEI


Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References