Detailed information of TA system TA126671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3166467..3167015
• Replicon: chromosome
• Accession: NZ_CP040690
• Organism: Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TFG5
• Locus tag: FF954_RS15045
• Protein ID: WP_003414602.1
• Coordinates: 3166752..3167015 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: O33347
• Locus tag: FF954_RS15040
• Protein ID: WP_003414599.1
• Coordinates: 3166467..3166748 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF954_RS15015 (FF954_15535)	3162090..3162947	-	858	WP_003899513.1	type I methionyl aminopeptidase	-
FF954_RS15020 (FF954_15540)	3162989..3163573	-	585	WP_003414585.1	DUF1707 domain-containing protein	-
FF954_RS15025 (FF954_15545)	3163677..3163925	+	249	WP_003913411.1	antitoxin VapB23	-
FF954_RS15030 (FF954_15550)	3163922..3164302	+	381	WP_003414592.1	type II toxin-antitoxin system VapC family toxin	-
FF954_RS15035 (FF954_15555)	3164384..3166195	-	1812	WP_003414596.1	penicillin-binding protein	-
FF954_RS15040 (FF954_15560)	3166467..3166748	+	282	WP_003414599.1	type II toxin-antitoxin system antitoxin RelF	Antitoxin
FF954_RS15045 (FF954_15565)	3166752..3167015	+	264	WP_003414602.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF954_RS15050 (FF954_15570)	3167388..3168242	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
FF954_RS15055 (FF954_15575)	3168298..3169461	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
FF954_RS15060 (FF954_15580)	3169478..3170692	-	1215	WP_003414610.1	zinc metalloprotease Rip	-
FF954_RS15065 (FF954_15585)	3170700..3171941	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10204.82 Da
• Isoelectric Point: 11.5078

>T126671 WP_003414602.1 NZ_CP040690:3166752-3167015 [Mycobacterium tuberculosis complex sp. N0153]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Nucleotide

• Length: 264 bp

>T126671 NZ_CP040690:3166752-3167015 [Mycobacterium tuberculosis complex sp. N0153]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10183.40 Da
• Isoelectric Point: 4.3440

>AT126671 WP_003414599.1 NZ_CP040690:3166467-3166748 [Mycobacterium tuberculosis complex sp. N0153]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Nucleotide

• Length: 282 bp

>AT126671 NZ_CP040690:3166467-3166748 [Mycobacterium tuberculosis complex sp. N0153]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Structures

Toxin

• PDB: 3G5O

Antitoxin

• PDB: 3G5O
• AlphaFold DB: A0A7U4BWP8