Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 2870072..2870781 | Replicon | chromosome |
| Accession | NZ_CP040690 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0153 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ26 |
| Locus tag | FF954_RS13440 | Protein ID | WP_003413164.1 |
| Coordinates | 2870072..2870485 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | FF954_RS13445 | Protein ID | WP_003413167.1 |
| Coordinates | 2870524..2870781 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF954_RS13410 (FF954_13885) | 2865782..2866096 | + | 315 | WP_009937839.1 | hypothetical protein | - |
| FF954_RS13415 (FF954_13890) | 2866392..2867603 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| FF954_RS13420 (FF954_13900) | 2867730..2868389 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| FF954_RS13425 (FF954_13905) | 2868386..2869045 | + | 660 | WP_003900847.1 | LppA family lipoprotein | - |
| FF954_RS13430 (FF954_13910) | 2869042..2869704 | + | 663 | WP_055351404.1 | LppA family lipoprotein | - |
| FF954_RS13435 (FF954_13915) | 2869701..2869979 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| FF954_RS13440 (FF954_13920) | 2870072..2870485 | + | 414 | WP_003413164.1 | PIN domain nuclease | Toxin |
| FF954_RS13445 (FF954_13925) | 2870524..2870781 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | Antitoxin |
| FF954_RS13450 (FF954_13930) | 2870778..2871155 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF954_RS13455 (FF954_13935) | 2871171..2871545 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| FF954_RS13460 (FF954_13940) | 2871645..2872040 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| FF954_RS13465 (FF954_13945) | 2872037..2872282 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| FF954_RS13470 (FF954_13955) | 2872693..2873112 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| FF954_RS13475 (FF954_13960) | 2873124..2873933 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| FF954_RS13480 (FF954_13965) | 2873930..2875186 | - | 1257 | WP_014585306.1 | endolytic transglycosylase MltG | - |
| FF954_RS13485 (FF954_13970) | 2875179..2875691 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15045.00 Da Isoelectric Point: 5.4673
>T126662 WP_003413164.1 NZ_CP040690:2870072-2870485 [Mycobacterium tuberculosis complex sp. N0153]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T126662 NZ_CP040690:2870072-2870485 [Mycobacterium tuberculosis complex sp. N0153]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT126662 WP_003413167.1 NZ_CP040690:2870524-2870781 [Mycobacterium tuberculosis complex sp. N0153]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT126662 NZ_CP040690:2870524-2870781 [Mycobacterium tuberculosis complex sp. N0153]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829C9W5 |