Detailed information of TA system TA126659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2404526..2405055
• Replicon: chromosome
• Accession: NZ_CP040690
• Organism: Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: FF954_RS11235
• Protein ID: WP_003411124.1
• Coordinates: 2404526..2404843 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: FF954_RS11240
• Protein ID: WP_003411127.1
• Coordinates: 2404840..2405055 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF954_RS11205 (FF954_11590)	2399663..2400739	+	1077	WP_003904789.1	hypothetical protein	-
FF954_RS11210 (FF954_11595)	2400736..2401017	+	282	WP_003411112.1	DUF5703 family protein	-
FF954_RS11215 (FF954_11600)	2401053..2402126	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
FF954_RS11220 (FF954_11605)	2402131..2402661	-	531	WP_003903767.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
FF954_RS11225 (FF954_11610)	2402709..2404055	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
FF954_RS11235 (FF954_11620)	2404526..2404843	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF954_RS11240 (FF954_11625)	2404840..2405055	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
FF954_RS11245 (FF954_11630)	2405310..2406368	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
FF954_RS11250 (FF954_11635)	2406498..2406854	-	357	WP_003411130.1	hypothetical protein	-
FF954_RS11255 (FF954_11640)	2406949..2407731	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
FF954_RS11260 (FF954_11645)	2407999..2408289	-	291	WP_003900476.1	YggT family protein	-
FF954_RS11265 (FF954_11650)	2408451..2409107	-	657	WP_003411133.1	cell division protein SepF	-
FF954_RS11270 (FF954_11655)	2409173..2409949	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T126659 WP_003411124.1 NZ_CP040690:c2404843-2404526 [Mycobacterium tuberculosis complex sp. N0153]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T126659 NZ_CP040690:c2404843-2404526 [Mycobacterium tuberculosis complex sp. N0153]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT126659 WP_003411127.1 NZ_CP040690:c2405055-2404840 [Mycobacterium tuberculosis complex sp. N0153]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT126659 NZ_CP040690:c2405055-2404840 [Mycobacterium tuberculosis complex sp. N0153]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4