Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2367779..2368474 Replicon chromosome
Accession NZ_CP040690
Organism Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FF954_RS11030 Protein ID WP_003410811.1
Coordinates 2367779..2368213 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FF954_RS11035 Protein ID WP_003410814.1
Coordinates 2368220..2368474 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF954_RS11020 (FF954_11405) 2363933..2366974 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
FF954_RS11025 (FF954_11410) 2366967..2367800 + 834 WP_003899172.1 SWIM zinc finger family protein -
FF954_RS11030 (FF954_11415) 2367779..2368213 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FF954_RS11035 (FF954_11420) 2368220..2368474 - 255 WP_003410814.1 antitoxin Antitoxin
FF954_RS11040 (FF954_11425) 2368490..2368747 - 258 WP_003410816.1 hypothetical protein -
FF954_RS11045 (FF954_11435) 2369694..2369989 + 296 Protein_2184 PE family protein -
FF954_RS11050 (FF954_11440) 2370045..2370776 + 732 WP_003900467.1 PPE family protein -
FF954_RS11055 (FF954_11445) 2371316..2372062 - 747 WP_003901330.1 proteasome subunit alpha -
FF954_RS11060 (FF954_11450) 2372059..2372934 - 876 WP_003411023.1 proteasome subunit beta -
FF954_RS11065 (FF954_11455) 2372931..2373125 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T126658 WP_003410811.1 NZ_CP040690:c2368213-2367779 [Mycobacterium tuberculosis complex sp. N0153]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T126658 NZ_CP040690:c2368213-2367779 [Mycobacterium tuberculosis complex sp. N0153]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT126658 WP_003410814.1 NZ_CP040690:c2368474-2368220 [Mycobacterium tuberculosis complex sp. N0153]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT126658 NZ_CP040690:c2368474-2368220 [Mycobacterium tuberculosis complex sp. N0153]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References