Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2231302..2232200 Replicon chromosome
Accession NZ_CP040690
Organism Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FF954_RS10420 Protein ID WP_003410001.1
Coordinates 2231302..2231862 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FF954_RS10425 Protein ID WP_003410003.1
Coordinates 2231859..2232200 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF954_RS10395 (FF954_10770) 2227898..2228584 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
FF954_RS10400 (FF954_10775) 2228775..2229743 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
FF954_RS10405 (FF954_10780) 2229968..2230387 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin -
FF954_RS10410 (FF954_10785) 2230396..2230656 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin -
FF954_RS10415 (FF954_10790) 2230799..2231155 + 357 Protein_2058 PE family protein -
FF954_RS10420 (FF954_10795) 2231302..2231862 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FF954_RS10425 (FF954_10800) 2231859..2232200 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FF954_RS10430 (FF954_10805) 2232286..2232543 + 258 WP_003410006.1 hypothetical protein -
FF954_RS10435 (FF954_10810) 2232444..2232779 - 336 WP_003410009.1 dehydrogenase -
FF954_RS10440 (FF954_10815) 2232868..2233212 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FF954_RS10445 (FF954_10820) 2233206..2233454 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FF954_RS10450 (FF954_10825) 2233554..2235869 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FF954_RS10455 (FF954_10830) 2235866..2236138 - 273 WP_003903706.1 DUF1490 family protein -
FF954_RS10460 (FF954_10835) 2236191..2236547 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T126653 WP_003410001.1 NZ_CP040690:c2231862-2231302 [Mycobacterium tuberculosis complex sp. N0153]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T126653 NZ_CP040690:c2231862-2231302 [Mycobacterium tuberculosis complex sp. N0153]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT126653 WP_003410003.1 NZ_CP040690:c2232200-2231859 [Mycobacterium tuberculosis complex sp. N0153]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT126653 NZ_CP040690:c2232200-2231859 [Mycobacterium tuberculosis complex sp. N0153]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References