Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2203740..2204284 | Replicon | chromosome |
| Accession | NZ_CP040690 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0153 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FF954_RS10255 | Protein ID | WP_003409896.1 |
| Coordinates | 2203740..2204036 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FF954_RS10260 | Protein ID | WP_003409899.1 |
| Coordinates | 2204033..2204284 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF954_RS10200 (FF954_10555) | 2198773..2199123 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FF954_RS10205 (FF954_10560) | 2199134..2200036 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| FF954_RS10210 (FF954_10565) | 2200057..2200248 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FF954_RS10215 (FF954_10570) | 2200249..2200545 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FF954_RS10220 (FF954_10575) | 2200785..2201000 | + | 216 | WP_003409878.1 | antitoxin | - |
| FF954_RS10225 (FF954_10580) | 2200997..2201308 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF954_RS10230 | 2201282..2201803 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FF954_RS10235 (FF954_10590) | 2201778..2202155 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FF954_RS10240 (FF954_10595) | 2202197..2202646 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FF954_RS10245 (FF954_10600) | 2202643..2203188 | + | 546 | WP_031663732.1 | hypothetical protein | - |
| FF954_RS10250 (FF954_10605) | 2203077..2203691 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FF954_RS10255 (FF954_10610) | 2203740..2204036 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FF954_RS10260 (FF954_10615) | 2204033..2204284 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FF954_RS10265 (FF954_10620) | 2204271..2204765 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FF954_RS10270 (FF954_10625) | 2204925..2205332 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF954_RS10275 (FF954_10630) | 2205336..2205608 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FF954_RS10280 (FF954_10635) | 2205641..2206861 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FF954_RS10285 (FF954_10650) | 2207760..2208557 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T126651 WP_003409896.1 NZ_CP040690:c2204036-2203740 [Mycobacterium tuberculosis complex sp. N0153]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T126651 NZ_CP040690:c2204036-2203740 [Mycobacterium tuberculosis complex sp. N0153]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT126651 WP_003409899.1 NZ_CP040690:c2204284-2204033 [Mycobacterium tuberculosis complex sp. N0153]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT126651 NZ_CP040690:c2204284-2204033 [Mycobacterium tuberculosis complex sp. N0153]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |