Detailed information of TA system TA126642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1388056..1388615
• Replicon: chromosome
• Accession: NZ_CP040690
• Organism: Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: FF954_RS06625
• Protein ID: WP_003898789.1
• Coordinates: 1388056..1388349 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FF954_RS06630
• Protein ID: WP_003406322.1
• Coordinates: 1388346..1388615 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF954_RS06600 (FF954_06810)	1383649..1383909	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FF954_RS06605 (FF954_06815)	1383906..1384337	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FF954_RS06610 (FF954_06820)	1384360..1386048	-	1689	WP_096362018.1	PE family protein	-
FF954_RS06615 (FF954_06830)	1386228..1387088	+	861	WP_003903377.1	glycine betaine ABC transporter substrate-binding protein	-
FF954_RS06620 (FF954_06835)	1387169..1387999	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FF954_RS06625 (FF954_06840)	1388056..1388349	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FF954_RS06630 (FF954_06845)	1388346..1388615	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF954_RS06635 (FF954_06850)	1388728..1392423	-	3696	WP_015631286.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FF954_RS06640 (FF954_06855)	1392565..1393353	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T126642 WP_003898789.1 NZ_CP040690:c1388349-1388056 [Mycobacterium tuberculosis complex sp. N0153]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T126642 NZ_CP040690:c1388349-1388056 [Mycobacterium tuberculosis complex sp. N0153]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT126642 WP_003406322.1 NZ_CP040690:c1388615-1388346 [Mycobacterium tuberculosis complex sp. N0153]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT126642 NZ_CP040690:c1388615-1388346 [Mycobacterium tuberculosis complex sp. N0153]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2