Detailed information of TA system TA126641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1383649..1384337
• Replicon: chromosome
• Accession: NZ_CP040690
• Organism: Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FF954_RS06605
• Protein ID: WP_003406304.1
• Coordinates: 1383906..1384337 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FF954_RS06600
• Protein ID: WP_003406302.1
• Coordinates: 1383649..1383909 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF954_RS06580 (FF954_06790)	1379226..1380050	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FF954_RS06585 (FF954_06795)	1380055..1381236	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FF954_RS06590 (FF954_06800)	1381313..1382413	-	1101	WP_286499421.1	magnesium/cobalt transporter CorA	-
FF954_RS06595 (FF954_06805)	1382584..1383573	+	990	WP_003406301.1	malate dehydrogenase	-
FF954_RS06600 (FF954_06810)	1383649..1383909	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FF954_RS06605 (FF954_06815)	1383906..1384337	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF954_RS06610 (FF954_06820)	1384360..1386048	-	1689	WP_096362018.1	PE family protein	-
FF954_RS06615 (FF954_06830)	1386228..1387088	+	861	WP_003903377.1	glycine betaine ABC transporter substrate-binding protein	-
FF954_RS06620 (FF954_06835)	1387169..1387999	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FF954_RS06625 (FF954_06840)	1388056..1388349	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FF954_RS06630 (FF954_06845)	1388346..1388615	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T126641 WP_003406304.1 NZ_CP040690:1383906-1384337 [Mycobacterium tuberculosis complex sp. N0153]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T126641 NZ_CP040690:1383906-1384337 [Mycobacterium tuberculosis complex sp. N0153]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT126641 WP_003406302.1 NZ_CP040690:1383649-1383909 [Mycobacterium tuberculosis complex sp. N0153]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT126641 NZ_CP040690:1383649-1383909 [Mycobacterium tuberculosis complex sp. N0153]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6