126635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 843423..844132 Replicon chromosome
Accession NZ_CP040690
Organism Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4F979
Locus tag FF954_RS03970 Protein ID WP_003903160.1
Coordinates 843704..844132 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag FF954_RS03965 Protein ID WP_003403834.1
Coordinates 843423..843680 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF954_RS03955 (FF954_04060) 839125..840144 + 1020 Protein_782 PE family protein -
FF954_RS03960 (FF954_04070) 840543..843332 + 2790 WP_031653738.1 PE family protein -
FF954_RS03965 (FF954_04075) 843423..843680 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
FF954_RS03970 (FF954_04080) 843704..844132 + 429 WP_003903160.1 type II toxin-antitoxin system VapC family toxin Toxin
FF954_RS03975 (FF954_04085) 844213..844350 - 138 WP_003403839.1 hypothetical protein -
FF954_RS03980 (FF954_04090) 844509..844754 + 246 WP_003403841.1 hypothetical protein -
FF954_RS03985 (FF954_04095) 844823..845707 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
FF954_RS03990 (FF954_04100) 845718..846890 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
FF954_RS03995 (FF954_04105) 846897..848429 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15799.21 Da        Isoelectric Point: 7.5536

>T126635 WP_003903160.1 NZ_CP040690:843704-844132 [Mycobacterium tuberculosis complex sp. N0153]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLVLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T126635 NZ_CP040690:843704-844132 [Mycobacterium tuberculosis complex sp. N0153]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT126635 WP_003403834.1 NZ_CP040690:843423-843680 [Mycobacterium tuberculosis complex sp. N0153]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT126635 NZ_CP040690:843423-843680 [Mycobacterium tuberculosis complex sp. N0153]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F979

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References