Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 717364..718013 Replicon chromosome
Accession NZ_CP040690
Organism Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FF954_RS03270 Protein ID WP_003403236.1
Coordinates 717618..718013 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FF954_RS03265 Protein ID WP_003403235.1
Coordinates 717364..717618 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF954_RS03240 712489..712572 + 84 Protein_642 galactose-1-phosphate uridylyltransferase -
FF954_RS03245 (FF954_03325) 712591..713673 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FF954_RS03250 (FF954_03330) 713670..714761 + 1092 WP_003900977.1 galactokinase -
FF954_RS03255 (FF954_03340) 715156..716313 + 1158 WP_003903091.1 hypothetical protein -
FF954_RS03260 (FF954_03345) 716324..717271 + 948 WP_003403232.1 DUF732 domain-containing protein -
FF954_RS03265 (FF954_03350) 717364..717618 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FF954_RS03270 (FF954_03355) 717618..718013 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FF954_RS03275 (FF954_03360) 718107..718847 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FF954_RS03280 (FF954_03365) 718979..719239 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FF954_RS03285 (FF954_03370) 719236..719643 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FF954_RS03290 (FF954_03375) 719715..720866 - 1152 WP_286499401.1 FIST N-terminal domain-containing protein -
FF954_RS03295 (FF954_03380) 720959..722686 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T126629 WP_003403236.1 NZ_CP040690:717618-718013 [Mycobacterium tuberculosis complex sp. N0153]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T126629 NZ_CP040690:717618-718013 [Mycobacterium tuberculosis complex sp. N0153]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT126629 WP_003403235.1 NZ_CP040690:717364-717618 [Mycobacterium tuberculosis complex sp. N0153]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT126629 NZ_CP040690:717364-717618 [Mycobacterium tuberculosis complex sp. N0153]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References