Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704197..704840 Replicon chromosome
Accession NZ_CP040690
Organism Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FF954_RS03185 Protein ID WP_003403187.1
Coordinates 704439..704840 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FF954_RS03180 Protein ID WP_003403184.1
Coordinates 704197..704442 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF954_RS03145 (FF954_03215) 699482..700012 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FF954_RS03150 (FF954_03220) 699996..700691 - 696 WP_003918099.1 two-component system response regulator TcrA -
FF954_RS03155 (FF954_03225) 700814..701125 + 312 WP_003403164.1 hypothetical protein -
FF954_RS03160 (FF954_03230) 701197..702147 + 951 WP_003907436.1 DUF1259 domain-containing protein -
FF954_RS03165 (FF954_03235) 702388..702967 + 580 Protein_627 IS607-like element IS1536 family transposase -
FF954_RS03170 (FF954_03240) 702969..703679 + 711 Protein_628 IS607 family element RNA-guided endonuclease TnpB -
FF954_RS03175 (FF954_03245) 703682..704152 + 471 WP_003898523.1 hypothetical protein -
FF954_RS03180 (FF954_03250) 704197..704442 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF954_RS03185 (FF954_03255) 704439..704840 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FF954_RS03190 (FF954_03260) 704831..705010 + 180 Protein_632 hypothetical protein -
FF954_RS03195 (FF954_03275) 705428..705625 - 198 WP_003403191.1 hypothetical protein -
FF954_RS03200 (FF954_03280) 705705..706862 - 1158 Protein_634 hypothetical protein -
FF954_RS03205 (FF954_03285) 706914..707135 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FF954_RS03210 (FF954_03290) 707277..707882 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T126627 WP_003403187.1 NZ_CP040690:704439-704840 [Mycobacterium tuberculosis complex sp. N0153]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T126627 NZ_CP040690:704439-704840 [Mycobacterium tuberculosis complex sp. N0153]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT126627 WP_003403184.1 NZ_CP040690:704197-704442 [Mycobacterium tuberculosis complex sp. N0153]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT126627 NZ_CP040690:704197-704442 [Mycobacterium tuberculosis complex sp. N0153]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References