Detailed information of TA system TA126619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 365674..366200
• Replicon: chromosome
• Accession: NZ_CP040690
• Organism: Mycobacterium tuberculosis complex sp. N0153

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: FF954_RS01590
• Protein ID: WP_003401560.1
• Coordinates: 365898..366200 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: FF954_RS01585
• Protein ID: WP_003401555.1
• Coordinates: 365674..365901 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF954_RS01570 (FF954_01605)	361322..362125	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
FF954_RS01575 (FF954_01610)	362135..363532	-	1398	WP_003401544.1	sulfatase	-
FF954_RS01580 (FF954_01615)	363711..365531	+	1821	WP_031653699.1	PE family protein	-
FF954_RS01585 (FF954_01620)	365674..365901	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
FF954_RS01590 (FF954_01625)	365898..366200	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
FF954_RS01595 (FF954_01630)	366248..366469	+	222	WP_055384816.1	type II toxin-antitoxin system antitoxin VapB2	-
FF954_RS01600 (FF954_01635)	366466..366891	+	426	WP_003401566.1	PIN domain nuclease	-
FF954_RS01605 (FF954_01640)	367027..367659	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
FF954_RS01610 (FF954_01645)	367656..368564	+	909	WP_003900117.1	protochlorophyllide reductase	-
FF954_RS01615	368572..369162	-	591	WP_229298012.1	hypothetical protein	-
FF954_RS01620	369155..369205	-	51	Protein_320	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T126619 WP_003401560.1 NZ_CP040690:365898-366200 [Mycobacterium tuberculosis complex sp. N0153]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T126619 NZ_CP040690:365898-366200 [Mycobacterium tuberculosis complex sp. N0153]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT126619 WP_003401555.1 NZ_CP040690:365674-365901 [Mycobacterium tuberculosis complex sp. N0153]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT126619 NZ_CP040690:365674-365901 [Mycobacterium tuberculosis complex sp. N0153]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1