Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3780538..3781067 | Replicon | chromosome |
| Accession | NZ_CP040689 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0072 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | FF952_RS17730 | Protein ID | WP_003417760.1 |
| Coordinates | 3780810..3781067 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | FF952_RS17725 | Protein ID | WP_003417757.1 |
| Coordinates | 3780538..3780813 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF952_RS17690 (FF952_18325) | 3777111..3777800 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| FF952_RS17695 (FF952_18330) | 3777987..3778358 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| FF952_RS17700 | 3778256..3778474 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| FF952_RS17705 (FF952_18340) | 3778501..3778761 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| FF952_RS17710 (FF952_18345) | 3778876..3779265 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| FF952_RS17715 (FF952_18350) | 3779279..3779572 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| FF952_RS17720 (FF952_18355) | 3779569..3780414 | - | 846 | WP_003905054.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| FF952_RS17725 (FF952_18360) | 3780538..3780813 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| FF952_RS17730 (FF952_18365) | 3780810..3781067 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| FF952_RS17735 (FF952_18370) | 3781109..3782299 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| FF952_RS17740 (FF952_18375) | 3782416..3782784 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| FF952_RS17745 (FF952_18380) | 3782781..3783332 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| FF952_RS17750 (FF952_18385) | 3783339..3783920 | - | 582 | WP_015631560.1 | ATP/GTP-binding protein | - |
| FF952_RS17755 (FF952_18390) | 3783901..3784269 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| FF952_RS17760 (FF952_18395) | 3784247..3784639 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T126615 WP_003417760.1 NZ_CP040689:3780810-3781067 [Mycobacterium tuberculosis complex sp. N0072]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T126615 NZ_CP040689:3780810-3781067 [Mycobacterium tuberculosis complex sp. N0072]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT126615 WP_003417757.1 NZ_CP040689:3780538-3780813 [Mycobacterium tuberculosis complex sp. N0072]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT126615 NZ_CP040689:3780538-3780813 [Mycobacterium tuberculosis complex sp. N0072]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|