Detailed information of TA system TA126611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3185214..3185762
• Replicon: chromosome
• Accession: NZ_CP040689
• Organism: Mycobacterium tuberculosis complex sp. N0072

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TFG5
• Locus tag: FF952_RS15140
• Protein ID: WP_003414602.1
• Coordinates: 3185499..3185762 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: O33347
• Locus tag: FF952_RS15135
• Protein ID: WP_003414599.1
• Coordinates: 3185214..3185495 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF952_RS15110 (FF952_15630)	3180837..3181694	-	858	WP_003899513.1	type I methionyl aminopeptidase	-
FF952_RS15115 (FF952_15635)	3181736..3182320	-	585	WP_003414585.1	DUF1707 domain-containing protein	-
FF952_RS15120 (FF952_15640)	3182424..3182672	+	249	WP_003913411.1	antitoxin VapB23	-
FF952_RS15125 (FF952_15645)	3182669..3183049	+	381	WP_003414592.1	type II toxin-antitoxin system VapC family toxin	-
FF952_RS15130 (FF952_15650)	3183131..3184942	-	1812	WP_003414596.1	penicillin-binding protein	-
FF952_RS15135 (FF952_15655)	3185214..3185495	+	282	WP_003414599.1	type II toxin-antitoxin system antitoxin RelF	Antitoxin
FF952_RS15140 (FF952_15660)	3185499..3185762	+	264	WP_003414602.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF952_RS15145 (FF952_15665)	3186135..3186989	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
FF952_RS15150 (FF952_15670)	3187045..3188208	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
FF952_RS15155 (FF952_15675)	3188225..3189439	-	1215	WP_003414610.1	zinc metalloprotease Rip	-
FF952_RS15160 (FF952_15680)	3189447..3190688	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10204.82 Da
• Isoelectric Point: 11.5078

>T126611 WP_003414602.1 NZ_CP040689:3185499-3185762 [Mycobacterium tuberculosis complex sp. N0072]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Nucleotide

• Length: 264 bp

>T126611 NZ_CP040689:3185499-3185762 [Mycobacterium tuberculosis complex sp. N0072]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10183.40 Da
• Isoelectric Point: 4.3440

>AT126611 WP_003414599.1 NZ_CP040689:3185214-3185495 [Mycobacterium tuberculosis complex sp. N0072]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Nucleotide

• Length: 282 bp

>AT126611 NZ_CP040689:3185214-3185495 [Mycobacterium tuberculosis complex sp. N0072]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Structures

Toxin

• PDB: 3G5O

Antitoxin

• PDB: 3G5O
• AlphaFold DB: A0A7U4BWP8