Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
| Location | 2886177..2886808 | Replicon | chromosome |
| Accession | NZ_CP040689 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0072 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ28 |
| Locus tag | FF952_RS13540 | Protein ID | WP_003413174.1 |
| Coordinates | 2886431..2886808 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | FF952_RS13535 | Protein ID | WP_003413167.1 |
| Coordinates | 2886177..2886434 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF952_RS13505 (FF952_13975) | 2882091..2882405 | + | 315 | WP_009937839.1 | hypothetical protein | - |
| FF952_RS13510 (FF952_13980) | 2882701..2883912 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| FF952_RS13515 (FF952_13990) | 2884039..2884698 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| FF952_RS13520 (FF952_13995) | 2884695..2885357 | + | 663 | WP_031698290.1 | LppA family lipoprotein | - |
| FF952_RS13525 (FF952_14000) | 2885354..2885632 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| FF952_RS13530 (FF952_14005) | 2885725..2886138 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
| FF952_RS13535 (FF952_14010) | 2886177..2886434 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | Antitoxin |
| FF952_RS13540 (FF952_14015) | 2886431..2886808 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| FF952_RS13545 (FF952_14020) | 2886824..2887198 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| FF952_RS13550 (FF952_14025) | 2887298..2887693 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| FF952_RS13555 (FF952_14030) | 2887690..2887935 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| FF952_RS13560 (FF952_14040) | 2888346..2888765 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| FF952_RS13565 (FF952_14045) | 2888777..2889586 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| FF952_RS13570 (FF952_14050) | 2889583..2890836 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| FF952_RS13575 (FF952_14055) | 2890829..2891341 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T126603 WP_003413174.1 NZ_CP040689:2886431-2886808 [Mycobacterium tuberculosis complex sp. N0072]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T126603 NZ_CP040689:2886431-2886808 [Mycobacterium tuberculosis complex sp. N0072]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT126603 WP_003413167.1 NZ_CP040689:2886177-2886434 [Mycobacterium tuberculosis complex sp. N0072]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT126603 NZ_CP040689:2886177-2886434 [Mycobacterium tuberculosis complex sp. N0072]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ28 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829C9W5 |